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Trends Microbiol. 1999 Aug;7(8):315-20.

Following the leader: bacterial protein export through the Sec pathway.

Author information

1
Institute of Molecular Biology and Biotechnology-FORTH, Iraklio, Crete, GR-71110, Greece. aeconomo@imbb.forth.gr

Abstract

Significant strides have been made during the past 20 years in our understanding of protein secretion across the bacterial inner membrane. Specialized chaperones select secretory polypeptide chains and usher them to a membrane-embedded preprotein translocase. This unique molecular machine envelops the polymeric substrate and migrates along its length in defined, energy-dependent steps. Consequently, preproteins are gradually pumped into the periplasm where they acquire their native, folded conformation.

PMID:
10431204
DOI:
10.1016/s0966-842x(99)01555-3
[Indexed for MEDLINE]

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