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Trends Biochem Sci. 1999 Aug;24(8):295-8.

Transfer RNAs and pathogenicity islands.

Author information

1
Dept of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107, USA. hou1@jeflin.tju.edu

Abstract

The tRNAs are central components in translation. In addition, they are essential for replication of retroviruses: tRNAs bind to viral genomes through their 3'-end sequences and act as primers for initiation of viral replication. Here, I discuss the possibility that tRNAs also play a role in the horizontal transfer of bacterial pathogenicity islands between different pathogens. Such a role would implicate tRNAs in DNA recombination.

PMID:
10431171
DOI:
10.1016/s0968-0004(99)01428-0
[Indexed for MEDLINE]

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