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Immunol Today. 1999 Aug;20(8):343-7.

Stem cell escalation enables HLA-disparate haematopoietic transplants in leukaemia patients.

Author information

1
Dept of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel. bfrisner@weizmann.weizmann.ac.il

Abstract

Resistance to engraftment of bone marrow transplants appears to be mediated by host-derived cytotoxic T-cell precursors that survive supralethal conditioning. Here, Yair Reisner and Massimo Martelli review engraftment studies showing that escalation of haematopoietic progenitor cell dose induces transplantation tolerance, thereby overcoming major genetic histocompatibility barriers.

PMID:
10431152
[Indexed for MEDLINE]

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