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Neurosci Lett. 1999 Jul 9;269(2):107-9.

No pathogenic mutations in the beta-synuclein gene in Parkinson's disease.

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Mayo Clinic Jacksonville, FL 32224, USA.


We present 11 families consistent with autosomal dominant inheritance of probable Parkinson's disease (PD). Although excluded as a cause of disease in these kindreds, mutations in the alpha-synuclein gene have been implicated in familial PD. The beta-synuclein gene is highly homologous, expressed in the nervous system and thus is a good candidate gene for PD. Multipoint linkage analysis was either equivocal or excluded 5q35 haplotype sharing among affected family members. Sequencing the translated exons of the beta-synuclein gene failed to identify any pathogenic mutation.

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