Format

Send to

Choose Destination
Neurology. 1999 Jul 22;53(2):396-401.

Encephalitis after hepatitis B vaccination: recurrent disseminated encephalitis or MS?

Author information

1
Fédération de Neurologie, Hôpital de la Salpêtrière and Faculté de Mëdecine Pitié-Salpêtrière (Paris VI) France.

Abstract

OBJECTIVE:

To describe clinical and MRI features of patients with a disease suggestive of CNS inflammation after hepatitis B vaccination.

METHODS:

Eight patients with confirmed CNS inflammation occurring less than 10 weeks after hepatitis B vaccination are described. They received follow-up clinically and on MRI for a mean period of 18 months.

RESULTS:

Clinical and MRI findings were compatible with acute disseminated encephalomyelitis. However, clinical follow-up, repeated MRI, or both showed the persistence of inflammatory activity, which makes this encephalitis more suggestive of MS than of acute disseminated encephalomyelitis.

CONCLUSION:

The persistent inflammatory activity observed clinically and on MRI in these patients is comparable with that usually observed in MS. Epidemiologic studies are currently testing the hypothesis of a triggering role of hepatitis B vaccination in CNS demyelination.

PMID:
10430433
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center