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Bioorg Med Chem. 1999 Jun;7(6):1237-40.

Synthesis and screening of a combinatorial library of naphthalene substituted chalcones: inhibitors of leukotriene B4.

Author information

1
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune, India.

Abstract

A combinatorial mini library of naphthalene substituted chalcones has been prepared by solution phase chemistry. Screening of these mixtures for leukotriene B4 inhibitory activity using human whole blood assay (HWBL) afforded a lead compound, 1-(6-butoxy-2-naphthyl)-3-(4-nitrophenyl)-prop-2-en-1-one (K4A3) with an IC50 value of 18.5 microM.

PMID:
10428396
[Indexed for MEDLINE]

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