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Transplantation. 1999 Jul 15;68(1):1-8.

Dendritic cells as regulators of immune reactivity: implications for transplantation.

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Thomas E. Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh Medical Center, Pennsylvania 15213, USA.


Dendritic cells are now regarded not only as the initiators but also as regulators of immune responses. They are potentially powerful tools for the therapeutic manipulation of immune reactivity in cancer, infectious disease, and allograft rejection. We provide a brief overview of the properties of dendritic cells, with emphasis on recently acquired information, then focus attention on their capacity to modulate immune reactivity, and its relevance to transplantation.

[Indexed for MEDLINE]

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