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Fertil Steril. 1999 Jul;72(1):41-6.

Comparison of finasteride and flutamide in the treatment of idiopathic hirsutism.

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1
Department of Gynecological Endocrinology, University of Brescia, Italy.

Abstract

OBJECTIVE:

To compare the effectiveness of finasteride and flutamide in the treatment of idiopathic hirsutism.

DESIGN:

Randomized study.

SETTING:

Department of Gynecological Endocrinology, University of Brescia, Italy.

PATIENT(S):

Forty-six women with idiopathic hirsutism were selected.

INTERVENTION(S):

Patients were assigned randomly to receive 5 mg of finasteride once daily or 250 mg of flutamide twice daily for 12 consecutive months.

MAIN OUTCOME MEASURE(S):

Hirsutism was evaluated at 6 and 12 months of therapy by measuring the Ferriman-Gallwey score and the terminal-hair diameters (microm) taken from different body areas. Blood samples were taken and side effects were monitored during the treatment.

RESULT(S):

Both finasteride and flutamide induced a statistically significant decrease in hirsutism scores and hair diameters at the end of 12 months. Finasteride reduced the Ferriman-Gallwey score by 20.5% at 6 months and by 34.2% at 12 months, and hair diameter by 18.9%-23.6% at 6 months and by 29.6%-37.9% at 12 months. Flutamide reduced the Ferriman-Gallwey score by 26.6% at 6 months and by 50.9% at 12 months, and hair diameter by 22.3%-28.2% at 6 months and by 47.7%-56.5% at 12 months. Flutamide did not induce hormonal variations, whereas finasteride increased T levels by 60% and decreased 3alpha-androstanediol glucuronide by 69.5% at 12 months.

CONCLUSION(S):

Both drugs were effective in the treatment of idiopathic hirsutism, but flutamide was more effective than finasteride.

PMID:
10428146
[Indexed for MEDLINE]
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