Format

Send to

Choose Destination
Int J Oncol. 1999 Sep;15(3):595-9.

Angiogenesis is prognostically important in vertical growth phase melanomas.

Author information

1
Department of Pathology, The Gade Institute, Haukeland Hospital, N-5021 Bergen, Norway.

Abstract

The association between microvessel density (MVD) and patient survival has recently been established for various types of human cancers. Immunohistochemical staining (factor-VIII related antigen) was performed on a series of 102 vertical growth phase melanomas and vessels were counted in <hot spot> areas. Increased MVD was associated with large histologic tumor diameter (p=0.006) and tumor ulceration (p=0.04). Further, high vascular density was significantly related to decreased patient survival (p=0.04), with borderline significance (p=0.10) in the final multivariate model. The results of this study suggest that microvessel density is of prognostic importance in aggressive vertical growth phase melanomas.

PMID:
10427146
DOI:
10.3892/ijo.15.3.595
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Spandidos Publications
Loading ...
Support Center