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Nat Med. 1999 Aug;5(8):888-94.

Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits.

Author information

1
Department of Anatomy and Neurobiology, University of California, Irvine 92697-1280, USA.

Abstract

Febrile (fever-induced) seizures affect 3-5% of infants and young children. Despite the high incidence of febrile seizures, their contribution to the development of epilepsy later in life has remained controversial. Combining a new rat model of complex febrile seizures and patch clamp techniques, we determined that hyperthermia-induced seizures in the immature rat cause a selective presynaptic increase in inhibitory synaptic transmission in the hippocampus that lasts into adulthood. The long-lasting nature of these potent alterations in synaptic communication after febrile seizures does not support the prevalent view of the 'benign' nature of early-life febrile convulsions.

PMID:
10426311
PMCID:
PMC3382971
DOI:
10.1038/11330
[Indexed for MEDLINE]
Free PMC Article

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