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Biochim Biophys Acta. 1999 Jul 30;1439(2):187-97.

The PLD superfamily: insights into catalysis.

Author information

1
Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. mwaite@wfubmc.edu

Abstract

Knowledge of the PLD superfamily is rapidly expanding and new insights into the mechanism and regulation of the superfamily are rapidly emerging. The recent structural analysis and use of mutant proteins suggest a mechanism that involves two active sites acting in concert. While a number of residues are required for activity, it appears most likely that a histidine is the residue that becomes covalently linked to phosphatidate in catalysis. Evidence for these proposals is covered in this article.

PMID:
10425395
DOI:
10.1016/s1388-1981(99)00094-3
[Indexed for MEDLINE]

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