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Eur J Pharmacol. 1999 Jun 11;374(1):71-5.

Tolerance induction by transdermal glyceryl trinitrate in rats.

Author information

1
Cardiology Unit, North Western Adelaide Health Service, The Queen Elizabeth Hospital, University of Adelaide, South Australia, Australia. ilande@tqehsmtp.tqeh.sa.gov.au

Erratum in

  • Eur J Pharmacol 1999 Aug 20;379(1):115.

Abstract

Mechanisms of mild glyceryl trinitrate tolerance in rats (transdermal application; 15 mg/day/2 days) were examined in isolated aortic rings contracted with phenylephrine. Tolerance to glyceryl trinitrate was comparable in both endothelium-intact and -denuded vessels; the maximum relaxation decreased to 70-80% and the EC50 increased 3-4-fold. There was minimal cross-tolerance to acetylcholine (1.7-fold increase in EC50) and none to sodium nitroprusside. The results suggest that mild tolerance to glyceryl trinitrate in rats is mediated by mechanisms which are predominantly endothelium-independent and which produce little activation of the cellular mechanism responsible for cross-tolerance.

PMID:
10422642
DOI:
10.1016/s0014-2999(99)00319-2
[Indexed for MEDLINE]

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