Send to

Choose Destination
Eur J Pharmacol. 1999 Jun 11;374(1):71-5.

Tolerance induction by transdermal glyceryl trinitrate in rats.

Author information

Cardiology Unit, North Western Adelaide Health Service, The Queen Elizabeth Hospital, University of Adelaide, South Australia, Australia.

Erratum in

  • Eur J Pharmacol 1999 Aug 20;379(1):115.


Mechanisms of mild glyceryl trinitrate tolerance in rats (transdermal application; 15 mg/day/2 days) were examined in isolated aortic rings contracted with phenylephrine. Tolerance to glyceryl trinitrate was comparable in both endothelium-intact and -denuded vessels; the maximum relaxation decreased to 70-80% and the EC50 increased 3-4-fold. There was minimal cross-tolerance to acetylcholine (1.7-fold increase in EC50) and none to sodium nitroprusside. The results suggest that mild tolerance to glyceryl trinitrate in rats is mediated by mechanisms which are predominantly endothelium-independent and which produce little activation of the cellular mechanism responsible for cross-tolerance.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center