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Curr Biol. 1999 Jul 15;9(14):R518-20.

Genetic recombination: Helicases and topoisomerases link up.

Author information

1
Imperial Cancer Research Fund Laboratories, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.

Abstract

RecQ helicases and topoisomerase III are both required for genome stability, particularly to prevent 'promiscuous' genetic recombination. A recent study demonstrates that, together, these enzymes can catalyse the interlinking of plasmid DNA, and suggests a novel mechanism for the control of recombination.

PMID:
10421567
DOI:
10.1016/s0960-9822(99)80325-x
[Indexed for MEDLINE]
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