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Zh Vyssh Nerv Deiat Im I P Pavlova. 1999 May-Jun;49(3):471-82.

[The behavioral changes and the EEG of the rat brain induced by hyperactivation of the amygdaloid body under noradrenergic deficiency].

[Article in Russian]

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Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow.


The brain NA deficit was produced by bilateral injection of 6-OHDA into the locus coeruleus. Three weeks later amygdala hyperactivation was initiated by local penicillin injection (1% solution, 0.5 mcl). Saline in the same volume was used in control groups in both cases. It was shown that the decrease in NA level facilitated the development of epileptiform activity in rat brain and appearance of immobility-related high-voltage spindles during waking. The amygdala hyperactivation after NA deprivation resulted in a decrease in exploratory activity and disruption of the reaction to novelty. The delta component of the EEG power spectrum increased. The alterations appeared 1-2 weeks after the experimental procedure and became more pronounced towards the end of the third week.

[Indexed for MEDLINE]

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