Format

Send to

Choose Destination
Osteoarthritis Cartilage. 1999 Jul;7(4):416-8.

Reduction in the structural changes of experimental osteoarthritis by a nitric oxide inhibitor.

Author information

1
Osteoarthritis Research Unit, Louis-Charles Simard Research Center, Centre hospitalier de l'Université de Montréal, Campus Notre-Dame, Montréal, Québec, Canada.

Abstract

OBJECTIVE:

To evaluate the in-vivo therapeutic efficacy of N -iminoethyl-L-Lysine (L-NIL), a selective inhibitor of inducible nitric oxide synthase (iNOS) in a dose response study, on the progression of lesions in the experimental osteoarthritic (OA) dog model.

DESIGN:

The sectioning of the anterior cruciate ligament of the right stifle joint of mongrel dogs was done by a stab wound. Dogs were separated into experimental groups: Group 1 received no treatment, Groups 2, 3, and 4 received oral L-NIL (0.3, 1 or 10mg/kg/day, respectively) starting immediately after surgery. The OA dogs were killed at 12 weeks after surgery.

RESULTS:

Macroscopically, L-NIL decreased the size of the cartilage lesions on condyles and plateaus. The histologic severity of the cartilage lesions was decreased in the L-NIL-treated dogs. This effect was more pronounced at the highest dosage tested (3 and 10mg/kg/day).

CONCLUSIONS:

This study confirms the effectiveness of L-NIL, a selective inhibitor of iNOS, in attenuating the progression of experimental OA. It also clearly shows that the effect is dose-dependent.

PMID:
10419785
DOI:
10.1053/joca.1998.0229
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center