Format

Send to

Choose Destination
Mech Dev. 1999 Jul;85(1-2):189-92.

Expression of Fgf4 during early development of the chick embryo.

Author information

1
MRC Brain Development Programme, Department of Developmental Neurobiology, Guy's, King's and St. Thomas' Hospital Medical School, Hodgkin Building, Guy's Campus, London SE1 9RT, UK.

Abstract

Fibroblast growth factor 4 (Fgf4) has been implicated as a regulator of mesoderm formation, posteriorisation, neural induction and neural patterning. Much of the evidence for this derives from studies in which exogenous FGF4 is applied to avian embryos. We have therefore examined expression of endogenous Fgf4 mRNA in the developing chick embryo at stages when these processes are occurring. Expression was detected in the primitive streak from the onset of gastrulation. Notably, transient expression of transcripts was found in head process cells at the onset of neural plate formation and regionalisation. Later, mRNA was detected in the presumptive posterior hindbrain and within the ventral midbrain. Fgf4 mRNA was also found in paraxial mesoderm underlying the posterior hindbrain, somites, branchial arches, limb buds and the tail bud.

PMID:
10415361
DOI:
10.1016/s0925-4773(99)00093-3
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center