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Exp Neurol. 1999 Aug;158(2):529-33.

Activated astrocytes display increased 5-HT2a receptor expression in pathological states.

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Department of Pathological Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom.


In human brain tissues from patients dying with cerebral infarction, hypertensive encephalopathy, Alzheimer's disease, Huntington's disease, frontotemporal dementia, and Creutzfeldt-Jakob disease there is an activation of astrocytes. Such activated astrocytes display GFAP and strong 5-HT(2A), but not 5-HT(2B) or 5-HT(2C), receptor immunoreactivity; this 5-HT(2A) reaction has not been observed in normal, nonactivated astrocytes. It is suggested that an up-regulation of 5-HT(2A) receptors may be part of an early response reaction in astrocytes, possibly designed to maintain homeostasis or to induce secondary message pathways involving trophic factors or glycogenolysis.

[Indexed for MEDLINE]

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