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Ann N Y Acad Sci. 1999 Apr 30;868:483-93.

Glutamate receptor anchoring proteins and the molecular organization of excitatory synapses.

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1
Howard Hughes Medical Institute, Massachussets General Hospital, Boston 02114, USA. sheng@helix.mgh.harvard.edu

Abstract

Ionotropic glutamate receptors are concentrated at postsynaptic sites in excitatory synapses. The cytoplasmic C-terminal tail of certain glutamate receptor subunits interact with specific PDZ domain-containing proteins. NMDA receptor NR2 subunits bind to the PSD-95 family of proteins, whereas AMPA receptor subunits GluR2/3 bind to GRIP. These interactions may underlie the clustering, targeting, and immobilization of the glutamate receptors at postsynaptic sites. By virtue of their multiple protein-binding domains (e.g., three PDZs in PSD-95 and seven PDZs in GRIP), PSD-95 and GRIP can function as multivalent proteins that organize a specific cytoskeletal and signaling complex associated with each class of glutamate receptor. The network of protein-protein interactions mediated by these abundant PDZ proteins is likely to contribute significantly to the molecular scaffold of the postsynaptic density.

PMID:
10414325
[Indexed for MEDLINE]
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