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Arch Dermatol. 1999 Jul;135(7):799-803.

Asymmetric periflexural exanthem of childhood: a clinical, pathologic, and epidemiologic prospective study.

Author information

1
Unité de Dermatologie Pédiatrique, Hôpital Pellegrin-Enfants, Bordeaux, France.

Abstract

OBJECTIVE:

To assess the clinical, pathologic, and epidemiologic features of asymmetric periflexural exanthem of childhood (APEC), a clinically distinctive eruption, especially its link with pityriasis rosea and pattern of transmission.

DESIGN:

A prospective case series, including an analysis of epidemiologic triggering factors and mode of transmission. Pathologic study, including immunohistochemistry of the inflammatory infiltrate.

SETTING:

A mixed, community-based referral center.

PATIENTS:

A total of 37 girls and 30 boys with typical APEC referred from April 1994 to December 1996 were included in the study; 82% came from the greater Bordeaux area in France.

INTERVENTION:

None.

MAIN OUTCOME MEASURE:

Possible interhuman transmission of APEC.

RESULTS:

[corrected] No triggering factor was identified; no interhuman transmission occurred; and no demonstrable link with pityriasis rosea was apparent. Several new clinical variants were recognized or confirmed (high fever, facial and peripheral involvement, prolonged course). Distinctive perisudoral interface CD8+ infiltrate was suggestive of diagnosis.

CONCLUSIONS:

Interhuman transmission was doubtful, but inoculation disorder was still possible. Histopathologic findings seem more specific than previously thought.

PMID:
10411154
DOI:
10.1001/archderm.135.7.799
[Indexed for MEDLINE]

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