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Genomics. 1999 Jul 15;59(2):187-92.

MLL2: A new mammalian member of the trx/MLL family of genes.

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Cardinal Bernardin Cancer Center, Loyola University Medical Center, 2160 South First Avenue, Maywood, Illinois 60153, USA.


We have identified a gene at chromosome band 19q13.1, which is closely related to MLL. MLL is located in a region of chromosome 11q23 that has partial synteny with chromosome 19q. We have named this gene at 19q13.1, MLL2. MLL2 encodes a protein that exhibits a high level of similarity to MLL over several important protein domains. MLL2 is also ubiquitously expressed among adult human tissues, as is MLL. MLL is a homologue of the Drosophila gene trithorax (trx), which encodes a regulator of homeotic gene expression. MLL is involved in chromosome rearrangements associated with leukemia in mammals. However, no MLL2 rearrangements associated with leukemia have been recorded.

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