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J Pept Res. 1999 Jun;53(6):641-6.

Serotonin uptake stimulating peptide found in plasma of normal individuals and in some autistic urines.

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Research Institute, University of Oslo, Rikshospitalet, Norway.


We have isolated a tripeptide from normal plasma and autistic urines which stimulates the uptake of serotonin (5-HT) into platelets. This peptide was purified by high-performance liquid chromatography (HPLC) and characterized by sequenation and mass-spectrometry. Synthetic peptide showed co-chromatography with the biological sample in the HPLC systems used. Close to 60% of the autistic children diagnosed using the Diagnostic Statistical Manual III-R had an increased HPLC peak eluting like this peptide in their urines compared with controls.

[Indexed for MEDLINE]

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