Format

Send to

Choose Destination
Trends Cell Biol. 1999 Aug;9(8):312-8.

Getting across the nuclear pore complex.

Author information

1
Baylor College of Medicine, Dept of Cell Biology, One Baylor Plaza, Houston, TX 77030, USA.

Abstract

The nuclear pore complex (NPC) connects the cytoplasm and nucleus through the nuclear envelope and serves as the pipeline for moving material between the two compartments. Macromolecules that move through the NPC range in size from the very small (for example, ions and ATP) to the very large (for example, ribonucleoprotein particle complexes). Unlike translocation across other organelle membranes, proteins do not have to be unfolded to be transported through the NPC, and the NPC also routinely transports large, multicomponent substrates in both directions. This review focuses on current understanding of the different mechanisms by which macromolecules move across the NPC.

PMID:
10407410
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center