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Bioorg Med Chem Lett. 1999 Jul 5;9(13):1819-24.

Structure-activity relationship analysis of substituted 4-quinolinamines, antagonists of immunostimulatory CpG-oligodeoxynucleotides.

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1
Department of Chemistry, Georgia State University, Atlanta 30303, USA.

Abstract

On the basis of a systematic SAR analysis of substituted quinolines, a derivative 32 was synthesized that shows half-maximal inhibition of the immunostimulatory effect of CpG-oligodeoxynucleotides in vitro at the concentration of 0.24 nM.

PMID:
10406648
[Indexed for MEDLINE]
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