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Ukr Biokhim Zh (1978). 1998 Nov-Dec;70(6):135-43.

[Dynamics of the interaction of polyreactive immunoglobulins with immobilized antigens].

[Article in Russian]

Author information

1
O.V. Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv. sab@biochem.kiev.ua

Abstract

The kinetic of polyreactive immunoglobulins (PRIG) and immobilized antigen interaction was examined at different temperatures. It was shown that this process can be described by the so-called "competitive" model, and the relatively simple method for the rate constant determination for this process was developed. According to the "competitive" model PRIG molecule could be either in "active" or in "inactive" state and dynamic equilibrium exist between "active" and "inactive" molecules which strongly depend on incubation temperature. Only "active" PRIG can interact with antigens, and this is the reason of strong temperature dependence of PRIG-antigen interaction. The data also show that the mechanism of PRIG-antigen interaction differ from that of antibody-antigen interaction.

PMID:
10402663
[Indexed for MEDLINE]

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