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Clin Neurophysiol. 1999 Jun;110(6):1041-7.

Visual P300 latency predicts treatment response to modafinil in patients with narcolepsy.

Author information

1
Sleep Disorders Institute and Sangal Research Foundation, Troy, MI, USA.

Abstract

OBJECTIVE:

To evaluate the hypothesis that visual P300 latency (VL) predicts treatment response to modafinil (a new wake-promoting agent) in patients with narcolepsy.

METHODS:

DESIGN:

Comparison of responders and non-responders in a double-blind randomized placebo-controlled trial.

SETTING:

Private practice referral sleep disorders center.

PATIENTS:

Twenty one patients with narcolepsy (ages 17-65 years).

INTERVENTIONS:

Auditory and visual P300 testing using 31 evenly spaced scalp electrodes, and baseline polysomnograms and objective and subjective tests of daytime sleepiness, followed by modafinil treatment for 9 weeks. Polysomnograms and tests of sleepiness were then repeated.

MAIN OUTCOME MEASURE:

The Maintenance of Wakefulness Test (MWT). Response defined as a final MWT > 7.3min (normative sample mean - 3 SD), plus an increase > 1SD based on normative sample (3.6 min) over baseline MWT.

RESULTS:

Non-responders had longer age-adjusted 31-electrode mean VL (448.4 ms vs. 410.8 ms, P = 0.024), and larger auditory P300 amplitude, with no topographical P300 differences. Non-responders and responders did not differ on any other baseline clinical variable. Using a cut-off of 0.5 SE from normal regression constant, shorter age-adjusted VL predicted modafinil response, with specificity of 0.71 and sensitivity of 0.86.

CONCLUSIONS:

VL predicts treatment response to modafinil in patients with narcolepsy.

PMID:
10402091
[Indexed for MEDLINE]

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