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Rheumatology (Oxford). 1999 Jun;38(6):564-7.

Intra-articular absorption and distribution of ketoprofen after topical plaster application and oral intake in 100 patients undergoing knee arthroscopy.

Author information

1
Department of Orthopaedic Surgery, Huddinge University Hospital, Sweden.

Abstract

OBJECTIVE:

The primary objective of this study was to assess the kinetics of ketoprofen in synovial fluid and intra-articular tissues in relation to plasma. The secondary objective was to study whether intra-articular tissues act as reservoirs.

METHODS:

The ketoprofen concentration was analysed in plasma, synovial fluid and intra-articular tissues after single application of a 30 mg plaster (n = 40), multiple applications for 5 days (n = 30) or oral intake of 50 mg (n = 30) in patients undergoing knee arthroscopy.

RESULTS:

Median CMax values after topical application were 12.8 ng/ml in synovial fluid, 56.7 ng/g in synovial tissue, 349.3 ng/g in meniscus and 568.9 ng/g in cartilage.

CONCLUSION:

Topical applications of ketoprofen allow the attainment of high intra-articular tissue concentrations.

PMID:
10402079
[Indexed for MEDLINE]

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