Format

Send to

Choose Destination
See comment in PubMed Commons below
Genes Dev. 1999 Jul 1;13(13):1678-91.

Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana.

Author information

1
Department of Biology, Indiana University, Bloomington, Indiana 47405, USA.

Abstract

The plant hormone auxin regulates diverse aspects of plant growth and development. We report that in Arabidopsis, auxin response is dependent on a ubiquitin-ligase (E3) complex called SCFTIR1. The complex consists of proteins related to yeast Skp1p and Cdc53p called ASK and AtCUL1, respectively, as well as the F-box protein TIR1. Mutations in either ASK1 or TIR1 result in decreased auxin response. Further, overexpression of TIR1 promotes auxin response suggesting that SCFTIR1 is limiting for the response. These results provide new support for a model in which auxin action depends on the regulated proteolysis of repressor proteins.

PMID:
10398681
PMCID:
PMC316846
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center