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Rev Med Virol. 1997 Sep;7(3):167-180.

Cellular proteins in HIV virions.

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AIDS Vaccine Program, SAIC/Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA.


Human immunodeficiency virus type-1 (HIV-1) virions contain both virus-encoded and cellular proteins. Recent advances in the detection, isolation, and functional characterisation of host proteins incorporated in the virion have begun to provide for new perspectives on the interactions between virus and cell. The acquisition of host proteins by HIV-1 may also influence viral pathology in vivo. This article reviews detection and analysis of host proteins found in HIV-1 particles and presents some potential roles that these proteins might play in the biology of this important virus.

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