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J Pathol. 1999 Feb;187(3):272-8.

The transition from hyperplasia to invasive carcinoma of the breast.

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Department of Histopathology, University College London Medical School, U.K.


The multistep model of carcinogenesis in the breast suggests a transition from normal epithelium to invasive carcinoma via non-atypical and atypical hyperplasia and in situ carcinoma. Within the breast, these proliferations are heterogeneous in their cytological and architectural characteristics. This review considers the evidence supporting a precursor role for these preinvasive lesions.

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