Format

Send to

Choose Destination
Bioorg Med Chem Lett. 1999 Jun 21;9(12):1687-90.

Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes.

Author information

1
Department of Chemistry, Stanford University, CA 94305-5080, USA.

Abstract

Designed bryostatin analogues are assayed for binding affinity to individual cysteine rich domains of several protein kinase C (PKC) isozymes. These analogues exhibit significant selectivity for the PKCdelta-C1B peptide in terms of absolute affinity and the PKCdelta-C1A peptide in terms of relative affinity when compared to phorbol-12,13-dibutyrate.

PMID:
10397502
DOI:
10.1016/s0960-894x(99)00263-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center