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Curr Opin Neurobiol. 1999 Jun;9(3):299-304.

Roles of metabotropic glutamate receptors in LTP and LTD in the hippocampus.

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Department of Anatomy, MRC Centre for Synaptic Plasticity, University of Bristol School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK.


Metabotropic L-glutamate receptors are involved in various forms of synaptic plasticity in the hippocampus. The use of a new antagonist (LY341495) that blocks all known metabotropic L-glutamate receptors in the brain, together with subtype-selective antagonists, has identified multiple roles both for cloned and novel metabotropic L-glutamate receptors in hippocampal long-term potentiation and long-term depression.

[Indexed for MEDLINE]

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