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Curr Opin Neurobiol. 1999 Jun;9(3):343-8.

Structure, development, and plasticity of dendritic spines.

Author information

1
Division of Neuroscience in the Department of Neurology, Children's Hospital, 300 Longwood Avenue, Enders 260, Boston, Massachusetts 02115, USA. harrisk@hub.tch.harvard.edu

Abstract

Dendritic spines are distinguished by their shapes, subcellular composition, and synaptic receptor subtypes. Recent studies show that actin-dependent movements take place in spine heads, that spines emerge from stubby and shaft synapses after dendritic filopodia disappear, and that spines can form without synaptic activation, are maintained by optimal activation, and are lost with excessive activation or during degeneration.

PMID:
10395574
DOI:
10.1016/s0959-4388(99)80050-6
[Indexed for MEDLINE]

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