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Curr Opin Cell Biol. 1999 Jun;11(3):312-7.

Histone H1: location and role.

Author information

1
Department of Biochemistry & Cambridge Centre for Molecular Recognition, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK. jot1@bioc.cam.ac.uk

Abstract

Recent experiments have shown directly that, in bulk chromatin, the globular domain of histone H1 is positioned close to the dyad axis and is asymmetrically disposed, consistent with a polar arrangement of H1 molecules along the nucleosome filament. In addition to a structural role, H1 may also have gene-specific effects on transcription. The positioning of a core particle relative to a transcription factor binding-site may favour either transcription factor binding or H1 binding, depending on the location of the site.

PMID:
10395563
DOI:
10.1016/S0955-0674(99)80042-8
[Indexed for MEDLINE]

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