Format

Send to

Choose Destination
Curr Opin Cell Biol. 1999 Jun;11(3):330-5.

Activation of RNA polymerase II transcription.

Author information

1
Molecular Biology Institute, University of California, Los Angeles, 611 Charles E Young Drive East, BOX 951570, Los Angeles, CA 90095-1570, USA. berk@mbi.ucla.edu

Abstract

Multiple alternative interactions between activators and co-activators stimulate transcription by RNA polymerase II. In the past two years, multiprotein co-activator complexes have been characterized and their subunits defined. TATA-box binding protein associated factor (TAF) subunits of yeast TFIID were found to be generally required for transcription in vivo. Mammalian multisubunit coactivator complexes with homologs of the yeast SRB/Mediator subunits have been characterized. Structures of nuclear receptor-coactivator complexes have been determined.

PMID:
10395559
DOI:
10.1016/S0955-0674(99)80045-3
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center