Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Cell Biol. 1999 Jun;11(3):391-401.

The nuclear pore complex: from molecular architecture to functional dynamics.

Author information

  • 1Biozentrum, ME Müller Institute for Structural Biology, University of Basel, Klingelbergstrasse 70, CH-4056, Basel, Switzerland.


Toward dissecting the molecular composition and architecture of the nuclear pore complex (NPC), over the past 18 months novel nucleoporins and NPC subcomplexes were identified and characterized. The three-dimensional structure of isolated yeast NPCs was determined by electron cryomicroscopy. New specimen preparation and labeling protocols localized a number of nucleoporins and NPC subcomplexes within the three-dimensional architecture of the yeast NPC. Structural changes of native NPCs mediated by physiological effectors such as calcium or ATP were monitored by time-lapse atomic force microscopy, thus revealing a first glimpse of the NPC's functional dynamics.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center