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Curr Opin Cell Biol. 1999 Jun;11(3):318-24.

Telomerase and the maintenance of chromosome ends.

Author information

  • 1Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, Campus box 215, University of Colorado, Boulder, CO 80309-0215, USA. tracy.bryan@colorado.edu

Abstract

The catalytic subunit of telomerase has recently been identified in diverse eukaryotes and shown to be a reverse transcriptase. Ectopic expression of this protein in normal human cells leads to lengthened telomeres and an extended in vitro life span. Other proteins that modulate telomerase activity in vivo are also being identified, including a functionally conserved family of proteins with Myb-like DNA-binding domains and proteins that are involved in DNA double-strand break repair.

PMID:
10395557
DOI:
10.1016/S0955-0674(99)80043-X
[PubMed - indexed for MEDLINE]
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