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Curr Opin Cell Biol. 1999 Jun;11(3):385-90.

Structure and function of the nucleolus.

Author information

1
Department of Cell and Developmental Biology, Biocenter University of Würzburg, Am Hubland, D-97074, Würzburg, Germany. scheer@biozentrum.uni-wuerzburg.de

Abstract

The activity of the ribosomal RNA genes generates a distinct subnuclear structure, the nucleolus, which is the site of ribosome biogenesis. The signals that target proteins and snoRNAs (small nucleolar RNAs) to the nucleolus, the nuclear import of ribosomal proteins, the export of the completed ribosomal subunits and the molecular organization of the nucleolus have been the subject of intense research during the past year. Evidence is accumulating that nucleoli functionally interact with coiled bodies and are also involved in the maturation of non-ribosomal RNA species.

PMID:
10395554
DOI:
10.1016/S0955-0674(99)80054-4
[Indexed for MEDLINE]

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