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Am J Clin Nutr. 1999 Jul;70(1):49-52.

Serum vitamin C concentrations and diabetes: findings from the Third National Health and Nutrition Examination Survey, 1988-1994.

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1
Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. jxw6@cdc.gov

Abstract

BACKGROUND:

Previous studies suggested that diabetes mellitus may lower serum vitamin C concentrations, but most of these studies used clinic-based populations with established diabetes of varying duration and did not adjust for important covariates.

OBJECTIVE:

Using a population-based sample and adjusting for important covariates, we asked whether serum vitamin C concentrations in persons with newly diagnosed diabetes differed from those in persons without diabetes.

DESIGN:

Data were obtained from the third National Health and Nutrition Examination Survey (1988-1994). Serum vitamin C was assayed by using reversed-phase HPLC with multiwavelength detection. Diabetes status (n = 237 persons with diabetes; n = 1803 persons without diabetes) was determined by oral-glucose-tolerance testing of the sample aged 40-74 y.

RESULTS:

After adjustment for age and sex, mean serum vitamin C concentrations were significantly lower in persons with newly diagnosed diabetes than in those without diabetes. After adjustment for dietary intake of vitamin C and other important covariates, however, mean concentrations did not differ according to diabetes status.

CONCLUSION:

When assessing serum vitamin C concentrations by diabetes status in the future, researchers should measure and account for all factors that influence serum vitamin C concentrations.

PMID:
10393138
[Indexed for MEDLINE]
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