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Biochem Cell Biol. 1998;76(6):957-69.

The Cdx-1 and Cdx-2 homeobox genes in the intestine.

Author information

1
Institut National de la Santé et de la Recherche Médicale, Unité 381, Strasbourg, France. jean-noel.freund@inserm.u-strasbg.fr

Abstract

The past years have witnessed an increasing number of reports relative to homeobox genes in endoderm-derived tissues. In this review, we focus on the caudal-related Cdx-1 and Cdx-2 homeobox genes to give an overview of the in vivo, in vitro, and ex vivo approaches that emphasize their primary role in intestinal development and in the control of intestinal cell proliferation, differentiation, and identity. The participation of these genes in colon tumorigenesis and their identification as important actors of the oncogenic process are also discussed.

PMID:
10392709
DOI:
10.1139/o99-001
[Indexed for MEDLINE]

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