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Nature. 1999 Jun 24;399(6738 Suppl):A15-22.

Emerging insights into the genesis of epilepsy.

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Durham Veterans Affairs Medical Center, North Carolina 27710, USA.


Epilepsies are a diverse collection of brain disorders that affect 1-2% of the population. Current therapies are unsatisfactory as they provide only symptomatic relief, are effective in only a subset of affected individuals, and are often accompanied by persistent toxic effects. It is hoped that insight into the cellular and molecular mechanisms of epileptogenesis will lead to new therapies, prevention, or even a cure. Emerging insights point to alterations of synaptic function and intrinsic properties of neurons as common mechanisms underlying the hyperexcitability in diverse forms of epilepsy.

[Indexed for MEDLINE]

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