Format

Send to

Choose Destination
Pediatr Infect Dis J. 1999 Jun;18(6):487-9.

Viremia in neonatal herpes simplex virus infections.

Author information

1
Department of Medicine, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, USA.

Abstract

BACKGROUND:

Polymerase chain reaction assays of the peripheral blood mononuclear cells (PBMC) and plasma may facilitate the diagnosis of neonatal herpes simplex virus (HSV).

METHODS:

Assays for HSV DNA were submitted from at least 1 specimen site (PBMC, plasma or cerebrospinal fluid) in 11 consecutive cases of neonatal HSV infection.

RESULTS:

HSV DNA was detected by PCR in the PBMC of 6 of 10 infants tested (60%), the plasma of 4 of 6 tested (67%) and the cerebrospinal fluid of 4 of 11 tested (36%).

CONCLUSIONS:

HSV viremia is more frequent than previously appreciated, and detection of HSV DNA in PBMC and plasma is a useful diagnostic tool, particularly in infants without skin lesions.

PMID:
10391175
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center