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Nihon Rinsho. 1999 Jun;57(6):1381-6.

[TT virus infection in patients with hepatocellular carcinoma associated with non-A to G hepatitis: histopathological study].

[Article in Japanese]

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  • 1Third Department of Internal Medicine, Nihon University School of Medicine.


To study if TTV infection is involved in the development of hepatocellular carcinoma (HCC), we tested the sera of 19 patients with HCC associated with non-A to G hepatitis for the presence of serum TTV DNA, and compared the blood chemistry values and liver histology of the patients in the TTV DNA-positive and -negative groups. Detection of TTV DNA was performed described as Nishizawa, et al method. TTV DNA was detected in the sera of 47.4%. There were no significant differences in the blood chemistry results and other tests between the TTV-positive and -negative patients. Histological examination of the non-tumor regions of the liver showed that there were no significant differences in the number of areas and characteristics of the necro-inflammatory reactions, the degree of staging and irregular regeneration of hepatocyte between the two groups. These results suggest that the development of HCC in patients with non-A to G hepatitis is not associated with TTV infection.

[PubMed - indexed for MEDLINE]
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