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Rev Neurol. 1999 Jun 1-15;28(11):1033-5.

[Relationship between parenteral gangliosides administration and the Guillain-Barré syndrome].

[Article in Spanish]

Author information

1
Servicio de Neurología, Hospital de Santa Maria, Lisboa, Portugal.

Abstract

OBJECTIVE:

We carried out a case a case-control study to analyze the relationship between parenteral gangliosides administration and the Guillain-Barré syndrome.

PATIENTS AND METHODS:

We retrieved 64 patients with the diagnosis of Guillain-Barré syndrome, and 148 controls. In cases and controls the proportion and 95% confidence intervals (CI) of subject receiving gangliosides, was calculated. The number of patients with the Guillain-Barré syndrome who needed ventilation or died was also calculated.

RESULTS:

Four of 36 patients (95% CI = 81-0.6), over 40 years, received gangliosides prior to Guillain-Barré syndrome. One of these patients was ventilated (95% CI = 25-2) and died. None of the controls less than 40 years old took gangliosides, while from the 108 over 40 (95% CI = 15-4) 9 received gangliosides. None developed signs suggesting Guillain-Barré syndrome. Although gangliosides were more often used in Guillain-Barré syndrome (OR = 1.75), the difference was not significant (95% CI = 4.82-0.69).

CONCLUSION:

The present work proves that in spite of the association of Guillain-Barré syndrome, with gangliosides intake, there is no statistical difference between this group of patients and control population.

PMID:
10390766
[Indexed for MEDLINE]
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