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Trends Microbiol. 1999 Jul;7(7):292-7.

The cytolethal distending toxin family.

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Dept of Microbiology and Immunology, University of Kentucky, Lexington, KY 40536-0298, USA.


Cytolethal distending toxins are produced by a small but diverse group of bacterial pathogens. This newly discovered toxin family can cause a variety of mammalian cells to become irreversibly blocked in the G2 phase of the cell cycle. How this novel effect is accomplished is unknown but the study of these fascinating toxins promises to reveal new methods of host-pathogen interaction.

[Indexed for MEDLINE]

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