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Bioorg Med Chem Lett. 1999 Jun 7;9(11):1625-30.

Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production.

Author information

1
Celgene Corporation, Warren, NJ 07059, USA.

Abstract

Thalidomide, (1), is a known inhibitor of TNF-alpha release in LPS stimulated human PBMC. Herein we describe the TNF-alpha inhibitory activity of amino substituted analogs of thalidomide (1) and its isoindolin-1-one analog, EM-12 (2). The 4-amino substituted analogs were found to be potent inhibitors of TNF-alpha release in LPS stimulated human PBMC.

PMID:
10386948
[Indexed for MEDLINE]

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