Send to

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 1999 Jun 11;452(3):335-40.

Nuclear and nucleolar localization of Saccharomyces cerevisiae ribosomal proteins S22 and S25.

Author information

Department of Biochemistry and Molecular Biology, Institute for Molecular Biological Sciences, BioCentrum Amsterdam, Vrije Universiteit, The Netherlands.


Nuclear import usually relies on the presence of nuclear localization sequences (NLSs). NLSs are recognized by NLS receptors (importins), which target their substrates to the nuclear pore. We identified the NLSs of the yeast ribosomal proteins S22 and S25 and studied the former by mutational analysis. Furthermore, in S25 the nucleolar targeting information was found to overlap with its NLS. Comparison with previously published data on yeast ribosomal protein NLSs and computer analysis indicates the existence of a novel type of ribosomal protein-specific NLS that differs from the classical Chelsky and bipartite NLSs. The existence of such a ribosomal protein-specific NLS is in accordance with the recent identification of ribosomal protein-specific importins.

[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center