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Can Fam Physician. 1999 Jun;45:1451-3.

Safe use of valproic acid during pregnancy.

Author information

1
University of Toronto.

Abstract

QUESTION:

I have an epileptic patient who plans pregnancy. It took us years to control her seizures, and valproic acid seems to be the only way to control them. What is the risk to her fetus?

ANSWER:

Neural tube defects (NTDs) are the most common of the major anomalies associated with in utero exposure to valproic acid. About 1% to 2% of exposed fetuses suffer adverse effects.

PMID:
10386205
PMCID:
PMC2328449
[Indexed for MEDLINE]
Free PMC Article
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