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Eur J Clin Microbiol Infect Dis. 1999 Apr;18(4):296-8.

Short-term treatment of pertussis with azithromycin in infants and young children.

Author information

1
University Hospital for Infectious Diseases Dr. Fran Mihaljević, Zagreb, Croatia.

Abstract

A prospective, open, noncomparative study was conducted to assess the efficacy and safety of azithromycin given once daily for 3 or 5 days to eradicate Bordetella pertussis from the upper respiratory tract of infants and young children. Seventeen children received azithromycin in a dose of 10 mg/kg on day 1 followed by 5 mg/kg once daily for four consecutive days, and 20 were given 10 mg/kg once daily for 3 days. Seven days after the initiation of therapy, 33 of 35 (94.3%) patients had negative cultures for Bordetella pertussis. On day 14, cultures from all 34 evaluable patients were negative. These findings suggest that a controlled, comparative study of erythromycin versus short-term administration of azithromycin is justified.

PMID:
10385021
[Indexed for MEDLINE]

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