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Curr Opin Microbiol. 1999 Jun;2(3):312-6.

Multilocus sequence typing: molecular typing of bacterial pathogens in an era of rapid DNA sequencing and the internet.

Author information

1
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK. brian.spratt@zoo.ox.ac.uk

Abstract

Multilocus sequence typing is a development of multilocus enzyme electrophoresis in which the alleles at multiple house-keeping loci are assigned directly by nucleotide sequencing, rather than indirectly from the electrophoretic mobilities of their gene products. A major advantage of this approach is that sequence data are unambiguous and electronically portable, allowing molecular typing of bacterial pathogens (or other infectious agents) via the Internet.

PMID:
10383857
DOI:
10.1016/S1369-5274(99)80054-X
[Indexed for MEDLINE]

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