Format

Send to

Choose Destination
J Leukoc Biol. 1999 Jun;65(6):829-33.

Identification of CD137 as a potent monocyte survival factor.

Author information

1
Department of Pathology, University of Regensburg, Germany.

Abstract

CD137 (ILA/4-1BB), a member of the tumor necrosis factor (TNF) receptor family, promotes adherence and prolongs survival of human peripheral monocytes. It induces a strong expression of macrophage colony-stimulating factor (M-CSF), an essential monocyte survival factor. Monocyte survival induced by CD137 is primarily mediated by M-CSF and to a lesser extent by granulocyte-macrophage colony-stimulating factor and IL-3. Survival and induction of M-CSF are mediated via reverse signaling through a CD137 ligand expressed constitutively by peripheral monocytes.

PMID:
10380906
DOI:
10.1002/jlb.65.6.829
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center